The molar ratio of VWF:PP to VWF can be used as an indicator for the degradation of VWF. An increased ratio of VWF:PP / VWF indicates increased clearance of VWF. These are found in various patients with congenital VWF deficiency, but also in acquired VWF syndrome. An accurate knowledge of the clearance of VWF may influence the choice of therapy, in particular the need to administer VWF concentrates. Increased levels of VWF:PP or an abnormal ratio between VWF:PP and VWF may also be caused by activation of the endothelium or platelets.
